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Products IkBz Polyclonal Antibody
| Catalogue number: | 13926 |
| Hosts: | Rabbit |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide corresponding to mouse IkBz amino acids 684-699 and 285-298 |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | IkBz is an ankyrin repeat-containing nuclear protein that is highly homologous to the IkB family member Bcl-3. Transcription of IkBz is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkBz preferentially associates with the NF-kB subunit p50 rather than p65 and recombinant IkBz proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. |
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