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IkBz Polyclonal Antibody

Cat no: 13926

IkBz Polyclonal Antibody

Antigen: synthetic peptide corresponding to mouse IkBz amino acids 684-699 and 285-298 . Host: rabbit . Cross Reactivity: (+) mouse IkBz . Application(s): WB . IkBz preferentially associates with the NF-kB subunit p50 rather than p65 and recombinant IkBz proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. Transcription of IkBz is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells.

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SPECIFICATIONS

Catalog Number

13926

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|NF-.kappa.B|Intracellular Signaling

Weight

0

Antigen

synthetic peptide corresponding to mouse IkBz amino acids 684-699 and 285-298

Storage Temp

-20

Shipping Temp

-20

Additional Info

IkBz is an ankyrin repeat-containing nuclear protein that is highly homologous to the IkB family member Bcl-3. Transcription of IkBz is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkBz preferentially associates with the NF-kB subunit p50 rather than p65 and recombinant IkBz proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.

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