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Products IKK(gamma) Monoclonal Antibody (Clone 72C627)
| Catalogue number: | 13931 |
| Hosts: | Mouse |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | His-tagged full-length human IKK(gamma) |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Isotype: | IgG1 |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Nuclear Factor-kB (NF-kB) is sequestered in the cytoplasm by the IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB, thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IkB, releasing NF-kB dimers. NF-kB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). IKK(gamma) preferentially interacts with IKK(beta) and is required for activation of IKK complex. IKK(gamma) is also known as NF-kB essential modulator (NEMO). The human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKK(alpha) nor IKK(beta), but complexes directly with IKK(gamma). This suggests that IKK(gamma) may be a key molecule acting as an adapter for oncoprotein specific signaling to IKK(alpha) and IKK(beta). |
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