IKK(gamma) Monoclonal Antibody (Clone 72C627)

Antigen: His-tagged full-length human IKK(gamma) . Host: mouse, clone 72C627 . Isotype: IgG1 . Cross Reactivity: (+) human and mouse IKK(gamma) . Application(s): WB . IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). IKK(gamma) preferentially interacts with IKK(beta) and is required for activation of the IKK complex.

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SPECIFICATIONS

Catalog Number

13931

Applications

WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies|NF-.kappa.B|Intracellular Signaling

Weight

0

Antigen

His-tagged full-length human IKK(gamma)

Isotype

IgG1

Storage Temp

-20

Shipping Temp

-20

Additional Info

Nuclear Factor-kB (NF-kB) is sequestered in the cytoplasm by the IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB, thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IkB, releasing NF-kB dimers. NF-kB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IkB(alpha) is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/(alpha), IKK2/(beta), and IKK3/(gamma). IKK(gamma) preferentially interacts with IKK(beta) and is required for activation of IKK complex. IKK(gamma) is also known as NF-kB essential modulator (NEMO). The human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKK(alpha) nor IKK(beta), but complexes directly with IKK(gamma). This suggests that IKK(gamma) may be a key molecule acting as an adapter for oncoprotein specific signaling to IKK(alpha) and IKK(beta).