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Products iNOS Polyclonal Antibody
| Catalogue number: | 160862 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | purified enzyme from mouse macrophages (RAW 264.7) cells |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Nitric Oxide Synthase (NOS) catalyzes the biosynthesis of nitric oxide from L-arginine. Constitutively expressed NOS is found in brain (nNOS) and endothelial cells (eNOS). iNOS is a soluble enzyme found in a variety of tissues including macrophages, hepatocytes, vascular smooth muscle cells, and chondrocytes. iNOS expression is increased by a variety of factors including LPS, IFN-.gamma., Il-1.beta., and TNF-.alpha., whereas expression is deceased by dexamethasone. The enzyme has been cloned from several species including mouse, rat, and human with homology of at least 80% between these species. The calculated molecular weight of the protein from the deduced amino acid sequence is 130,000 - 131,000. |
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