Integrin alphaL, beta2, Recombinant, Human (LFA-1, CD11a/CD18)

Integrin alphaLbeta2 is one of three beta2 integrin adhesion proteins. The non-covalent heterodimer of 180kD aL/CD11a and 95kD b2/CD18 integrin subunits is expressed on virtually all leukocytes. The ligand binding site of LFA-1 is in the N-terminal head region, formed by an interaction of the vWFA (I, I-like) domains from each subunit, and the aL beta

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SPECIFICATIONS

Catalog Number

I7661-36R

Size

50ug

Form

Supplied as a lyophilized powder from 50mM Tris, 0.15M sodium chloride, 2mM magnesium chloride, pH 7.4. Reconstitute with 500ul sterile PBS. \n

Purity

~95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: (same/less than)1EU/ug (LAL).

References

US Biological Application References: 1. Gjelstrup, L.C., et al., J. Immunology 185: 4154-4168 (2010). General References: 1. Larson, R.S., et al., J. Cell Biol. 108: 703 (1989). 2. Kishimoto, T.K., et al., Cell 48: 681 (1987). 3. Hynes, R.O., Cell 110: 673 (2002). 4. Qu, A. & Leavy, D.J., Proc. Natl. Acad. Sci. USA 92: 10,277 (1995). 5. Shi, M., et al., J. Biol. Chem. 280: 30,586 (2005). 6. Beglova, N., et al., Nat. Struct. Biol. 9: 282 (2002). 7. Shimaoka, M., et al., Immunity 19: 391 (2003). 8. Lu, C., et al., J. Immunol. 173: 3972 (2004). 9. Cairo, C.W., et al., Immunity 25: 297 (2006). 10. Nortamo, P., et al., J. Immunol. 146: 2530 (1991). 11. de Fougerolles, A.R. & Springer, T.A., J. Exp. Med. 175: 185 (1992). 12. Ostermann, G., et al., Nat. Immunol. 3: 151 (2002). 13. Heit, B., et al., J. Cell Sci. 118: 5205 (2005). 14. Semmrich, M., et al., J. Exp. Med. 201: 1987 (2005). 15. Kishimoto, T.K., et al., Cell 50: 193 (1987).