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Products Interleukin-1(alpha) (human) EIA Kit
| Catalogue number: | 583301 |
| Weight: | 0 |
| Form: | 96 Well |
| P type: | Assay Kits|Cytokines |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Interleukin-1 (IL-1) is a name for a family of proteins which include IL-(alpha), IL-1(beta), ILra (interleukin receptor antagonist), and IL-18. IL-1(alpha) is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide. IL-1(alpha) is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils. Although IL-1(alpha) and IL-1(beta) exhibit only 26% amino acid identity, they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses. Normal production of IL-1 is critical for mediating host responses to infection and injury. Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer. Cayman |
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