Interleukin 1 beta, Recombinant, Chicken (Interleukin-1beta, IL1b, IL-1 beta, Il-1beta) (Azide Free)

Interleukin1 (IL1) is a proinflammatory cytokine secreted by many different cell types which acts upon a wide range of target cells, resulting in a diverse range of effects. The biological properties of IL1 include the induction of B cell proliferation, stimulation of T cell proliferation in conjunction with IL2 and the production of collagenase and prostaglandin by fibroblasts. IL1 is also responsible for triggering the acutephase response in the liver, and is involved in both cytokine network and vascular endothelium activation.\n\nI7663-08W induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL1beta antibody I7663-08V,\n\nSource: \nRecombinant corresponding to chicken IL-1 beta, histagged, expressed in E.coli.\n\nMolecular Weight: \n~23kD\n\nApplications:\nSuitable for use in Functional Assays and Immunoassays. Other applications not tested. \n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nStore at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I7663-08W

Size

50ug

Form

Supplied as a liquid in PBS. Preservative free.

Purity

Purified: ~85% (Ni chelate Chromatography)

References

1. Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin1 beta: cDNA cloning and purification of active recombinant protein. Eur. J. Biochem. 258: 9941000. 2. Gyorfy, Z. et al. (2003) Truncated chicken interleukin1 beta with increased biologic activity. J. Interferon and Cytokine Research 23: 223228.