Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant human IL-17A is a non-glycosylated, disulfide-linked, homodimer containingtwo 137 amino acid chainss , with a total molecular weight of 31 kD.\n\nEndotoxin: \n(same/less than) 0.1EU/ug (LAL)\n\nBiological Activity: \nThe ED50 as determined by the dose-dependent induction of IL-6 by mouse NIH 3T3 fibroblasts is 1.4-2.1 ng/ml\n\nAA Sequence:\nMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. For long term storage a carrier protein (0.1% BSA or HSA) is recommended. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I8439-02A

Size

5ug

Form

Supplied as a lyophilized powder with no additives. Reconstitute with sterile ddH2O to a concentration of 0.1mg/ml. For long term storage a carrier protein (0.1% BSA or HSA) is recommended.

Purity

(same/more than) 98% (HPLC, reducing and non-reducing SDS-PAGE)

References

1. Rouvier E, Luciani MF, Matt