Interleukin 1alpha, Recombinant, Human (IL-1 alpha, IL-1F1, FAF, BAF, LEM, LAF)

Interleukin-1 alpha (IL-1a) is constiutively expressed by epithlial cells, but can also be produced by most other cells upon stimulation. IL-1a and IL-1a are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1a is cell associated and IL-1bis secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. \n\nSource:\nRecombinant protein corresponding to 159aa from human IL-1a expressed in E.coli. \n\nMolecular Weight: \n~18kD\n\nEndotoxin:\n(same/less than)1EU/ug (LAL) \n\nBiological Activity:\nThe activity is determined by the stimulation of D10S.G4.1 cells and is typically 1-6pg/ml.\n\nAA Sequence:\nSAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKYQLY VTAQDEDQPV LLKEMPEKPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA\n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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