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Interleukin 31, Recombinant, Mouse (IL-31)

Cat no: 142934

Interleukin 31, Recombinant, Mouse (IL-31)

Interleukin-31 (IL-31) is an immunoregulatory cytokine that is mainly expressed by activated TH2 cells. IL-31 signals through the IL-31 Receptor (IL-31RA) and the oncostain receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 has a role in inflammatory skin diseases.\n\nRecombinant protein corresponding to 141aa from mouse IL-31 expressed in E.coli.\n\nBiological Activity:\nRecombinant IL-31 is fully biologically active. The ED50 determined by the dose dependent production of IL-31 by human PBMCs is 16-24pg/ml.\n\nAmino Acid Sequence:\nMTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C\n\nStorage and Stability: \nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

142934

Size

2ug

Form

Supplied as a lyophilized powder from 10mM sodium phosphate, pH 7.5. Reconstitute with sterile ddH2O to a concentration of 0.1mg/ml. For long term storage, add a carrier protein (0.1% HSA or BSA).

Purity

~97% (Reducing and non-reducing SDS-PAGE). Endotoxin: (same/less than)1EU/ug (LAL)

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