Supplier:
Cayman Chemical CompanyCat no: 10809
Interleukin-33 (human) Monoclonal Antibody (Clone IL33305B)
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SPECIFICATIONS
Catalog Number
10809
Applications
ELISA, IHC, IP, WB
Hosts
Mouse
Form
100 microg
P Type
Antibodies
Weight
0
Antigen
recombinant human IL-33
Isotype
IgG2ak
Storage Temp
-20
Shipping Temp
-20
Additional Info
Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy and anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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