Home  >  Products  >  Interleukin 6, Recombinant, Human (Interleukin-6, IL6, IL-6, B-cell Stimulatory Factor 2, BSF2, BSF-2, CTL Differentiation Factor, CDF, Hybridoma Growth Factor, HGF, HSF, Interferon beta-2, IFN-beta-2, IFNB2)

Interleukin 6, Recombinant, Human (Interleukin-6, IL6, IL-6, B-cell Stimulatory Factor 2, BSF2, BSF-2, CTL Differentiation Factor, CDF, Hybridoma Growth Factor, HGF, HSF, Interferon beta-2, IFN-beta-2, IFNB2)

Cat no: 149749


Supplier: United States Biological
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IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Ra and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9kD protein containing 184aa. Manufactured using all non-animal reagents. Source: Recombinant protein corresponding to human IL-6, expressed in E.coli. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells. The ED50 was found to be 0.1ng/ml Specific Activity: 1x10e7units/mg Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149749
Size: 20ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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