Interleukin 8, Recombinant, Human (IL-8, CXCL8, 310C, AMCF1, b-ENAP, Beta Thromboglobulin-like Protein, Emoctakin, Granulocyte Chemotactic Protein 1, GCP1, K60, LECT, LUCT, Lymphocyte-derived Neutrophil Activating Factor, LYNAP, MONAP, Monocyte Derived Ne

Interleukin 8/CXCL8 was originally discovered and purified independently by a number of laboratories as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T-lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of pro-inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (C-X-C) subfamily of chemokines, which also includes platelet factor 4, GRO, IP-10, etc.\n\nBiological Activity: \nFully biologically active when compared to standard. ED50 determined by its ability to chemoattract human peripheral blood neutrophils is (same/less than)100.0ng/ml.\n\nAA Sequence:\nSAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS\n\nSpecific Activity:\n~1.0x10e4 IU/mg\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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