IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant rat IP-10 is an 8.6kD protein consisting of 77aa including the four conserved cysteine residues present in CXC chemokines.
Source:
Recombinant protein corresponding to rat IP-10, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10-50ng/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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