Catalogue number: | 10239 |
Hosts: | Mouse |
Applications: | Immunocytochemistry, Western Blot |
Weight: | 0 |
Form: | 1 ea |
P type: | Antibodies|Intracellular Signaling |
Isotype: | IgG2bk |
Shipping temp: | -20 |
Storage temp: | -20 |
Additional info: | Inositol hexakisphosphate kinase 2 (IP6K2) is a cytoplasmic kinase that catalyzes the conversion of IP6 to diphosphoinositol pentakisphosphate in the presence of ATP. IP6K2 functions as a proapoptotic protein kinase. IP6K2 binds to tumor necrosis factor receptor-associated factor 2 and inhibits NF-kB signaling. Heat Shock Protein 90 regulates apoptosis through a normal physiological interaction with IP6K2 by inhibiting its catalytic activity. Thus, IP6K2 is a potential target for cancer therapeutics development. |