Cell-permeable. Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents b-catenin from switching coactivator usage from CBP to p300. The increase in b-cateinin/CBP mediated transcription at the expense of b- cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency.
Storage and Stability:
Lyophilized powder may be stored at 4 degrees C. Stable for 12 months at 4 degrees C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4 degrees C. Reconstituted product is stable for 6 months at 4 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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