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IQ-1 (2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide)

IQ-1 (2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide)

Cat no: I8565

Supplier: United States Biological
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Cell-permeable. Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents b-catenin from switching coactivator usage from CBP to p300. The increase in b-cateinin/CBP mediated transcription at the expense of b- cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency. Storage and Stability: Lyophilized powder may be stored at 4 degrees C. Stable for 12 months at 4 degrees C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4 degrees C. Reconstituted product is stable for 6 months at 4 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: I8565
Size: 1mg
Form: Supplied as an orange solid. Reconstitute with DMSO.
Purity: ~95% (HPLC)
Alternative names: 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide
References: 1. Miyabashi, T., et al. (2007). Proc. Natl. Acad. Sci. USA 104, 5668.

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