IRAK-1 Polyclonal Antibody

Antigen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712 . Host: rabbit . Cross Reactivity: (+) human and mouse IRAK-1; (-) IRAK-2 . Application(s): IP and WB . IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. It mediates a signaling cascade leading to NF-kB activation by members of the IL-1 family including IL-1 and IL-18.

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SPECIFICATIONS

Catalog Number

13843

Applications

IP, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|NF-.kappa.B|Intracellular Signaling

Weight

0

Antigen

synthetic peptide corresponding to human IRAK-1 amino acids 700-712

Storage Temp

4

Shipping Temp

4

Additional Info

Nuclear factor-kB (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-(alpha), and LPS. A serine/threonine protein kinase associated with interleukin-1 receptor-associated kinase 1 (IRAK-1) and its homologue murine pelle-like protein kinase (mPLK) has been identified. IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK-1 mediates a signaling cascade leading to NF-kB activation by members of the IL-1 family including IL-1 and IL-18 (also known as IGIF).