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Products IRAK-4 Polyclonal Antibody
| Catalogue number: | 13845 |
| Hosts: | Rabbit |
| Applications: | Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136 |
| P type: | Antibodies|NF-.kappa.B|Intracellular Signaling |
| Shipping temp: | 4 |
| Storage temp: | 4 |
| Additional info: | The toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1-4), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. A member of this family, IRAK-4 has been identified. IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges. |
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