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ITGB3BP, Recombinant, Human, aa1-216, His-Tag (Cntromere Protein R Isoform 1, CENP-R, CENPR, HSU37139, NRIF3, TAP20)

Cat no: 137096

ITGB3BP, Recombinant, Human, aa1-216, His-Tag (Cntromere Protein R Isoform 1, CENP-R, CENPR, HSU37139, NRIF3, TAP20)

Centromere protein R isoform 1, also known as ITGB3BP1, is a widely expressed protein that contains a DD1 or RepD1 domain and an LXXLL motif. Induced by estrogen, ITGB3BP1 is believed to function as a nuclear receptor coactivator. It also associates with the CENP-A-CAD complex which is involved in mitotic progression, the assembly of kinetochore proteins and chromosome segregation. It acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. \n\nSource: \nRecombinant protein corresponding to human ITGB3BP1, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~27.1kD (239aa) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMPFAPVA QARVQWHDFR SLQHLLPAFK RFSCLSLGSS WDYSVKRSLK LDGLLEENSF DPSKITRKKS VITYSPTTGT CQMSLFASPT SSEEQKHRNG LSNEKRKKLN HPSLTESKES TTKDNDEFMM LLSKVEKLSE EIMEIMQNLS SIQALEGSRE LENLIGISCA SHFLKREMQK TKELMTKVNK QKLFEKSTGL PHKASRHLDS YEFLKAILN\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137096

Size

20ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Foltz D R., et al. (2006) Nat Cell Biol. 8:458-469.

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