JMJD7 (JmjC Domain-containing Protein 7, Jumonji Domain-containing Protein 7)

Covalent modification and methylation of histones are crucial regulators of chromatin dynamics and DNA transcription. JMJD7, a member of a family of JMJC domain-containing histone demethylases, is directly involved in removing methyl residues from distinct and unique lysine residues. These actions are thought to have a role in gene expression and the regulation of cell senescence. JMJC domain-containing histone demethylases are also likely involved in development via their ability to regulate gene expression. Methylation of certain lysine residues on Histone H3 and H4 are often associated with transcripticonjugated to KLHonally active or inactive chromatin which can have profound effects on the expression of genes. JMJD7 contains one JMJC domain and initially thought to be an alternatively spliced isoform of PLA2G4B.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.1ug/ml \nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nRaji cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

029521

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Lakshminarayan, M.I., et al. (2010). Nucleic Acid Research. 38(16):5261-5279. 2. Klose, R., et al. (2006). Nature Reviews. 7:715-727. 3. Takeuchi, T., et al. (2006). Developmental Dyanmics. 235(9):2449-2459.

Additional Info

Recognizes human JMJD7. Species Crossreactivity: mouse and rat. Species sequence homology: chimpanzee, equine, rhesus macaque, marmoset, orangutan (100%).