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Kos1 (Kinase of Embryonic Stem Cells, CD38 Negative Kinase 1, EC 2.7.10.2, MGC46193, Non-receptor Tyrosine Protein Kinase TNK1, Tyrosine Kinase Non-receptor 1, Tnk 1)

Cat no: K1893-93B

Kos1 (Kinase of Embryonic Stem Cells, CD38 Negative Kinase 1, EC 2.7.10.2, MGC46193, Non-receptor Tyrosine Protein Kinase TNK1, Tyrosine Kinase Non-receptor 1, Tnk 1)

Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47kD protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

K1893-93B

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Mouse

Form

As reported

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Hoare, K. et al. Oncogene 22 (23), 3562-3577 (2003).

Additional Info

This antibody is specific for Kos1 (tnk1)

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SUPPLIER INFO

United States Biological

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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