LDB3, ID (LDB3, KIAA0613, ZASP, LIM domain-binding protein 3, Protein cypher, Z-band alternatively spliced PDZ-motif protein) (FITC)

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

037723-FITC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)\nZimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)\nVihola, A., et al. Acta Neuropathol. 119(4):465-479(2010)\nRampersaud, E., et al. Ann. Hum. Genet. 74(2):110-116(2010)\nAurino, S., et al. Acta Myol 27, 90-97 (2008) :

Additional Info

Human

Alternative Names

LDB3, KIAA0613, ZASP, LIM domain-binding protein 3, Protein cypher, Z-band alternatively spliced PDZ-motif protein