Leptin, Recombinant, Mouse (Ob, Obese Protein, Obesity Factor)

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Recombinant murine leptin is a 16.2kD protein containing 147 amino acid residues.\n\nBiological Activity: \nMurine leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5ug leptin/g of body weight for 7 days. Significant effects on body weight, food consumption and plasma glucose levels were observed compared to saline-treated controls.\n\nAmino Acid Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC\n\nStorage and Stability: \nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\nCountry of Origin: USA

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SPECIFICATIONS

Catalog Number

L1670-10

Size

200ug

Form

Supplied as a lyophilized powder from 0.1% TFA.\nReconstitute with sterile dH2O to a concentration of 1-5mg/ml. This solution can then be diluted into other aqueous solutions.

Purity

(same/more than) 95% by SDS-PAGE and HPLC. Endotoxin: (same/less than) 0.1ng/ug.