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Leukotriene A4 Hydrolase, Recombinant, Human (LTA4H)

Cat no: L2045-85

Leukotriene A4 Hydrolase, Recombinant, Human (LTA4H)

Leukotrienes are a family of lipid mediators important in a variety of allergic and inflammatory reactions. Synthesized by leukocytes, these molecules are divided into two classes, the spasmogenic cysteinyl leukotrienes and LTB4, a classical chemoattractant (1). Encoded by the LTA4H gene, leukotriene A4 hydrolase catalyzes the conversion of unstable epoxide LTA4 to LTB4, which is the final and committed step in LTB4 biosynthesis. As a bifunctional zinc metalloenzyme, LTA4H also acts as an arginyl aminopeptidase (2). LTA4H is a drug target for anti-inflammation, and for cancer prevention and therapy (1,3). The mature chain of human LTA4H consists of 610 amino acids (residues 2

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SPECIFICATIONS

Catalog Number

L2045-85

Size

10ug

Form

Supplied as a liquid in 12.5mM Tris, 75mM sodium chloride, 50% glycerol, pH 8.0.

Purity

(same/more than) 95%, as determined by SDS-PAGE and visualized by silver stain.

References

1. Haeggstrom, J.Z. (2006) J. Biol. Chem. 279:50639. \n2. Orning, L. et al. (1994) J. Biol. Chem. 269:11269. \n3. Chen, X. et al. (2004) Curr. Cancer Drug Targets 4:267. \n4. Ahmed, S. et al. (2006) FEBS J. 273:615.

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