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Leukotriene B4 Receptor 1 (LTB4R1, LTB4-R 1, LTB4-R1, LTBR1, Leukotriene B4 Receptor, LTB4R, BLT, BLT1, BLTR, Chemoattractant Receptor-like 1, CMKRL1, G-protein Coupled Receptor 16, GPR16, P2Y Purinoceptor 7, P2RY7, P2Y7)

Cat no: L2046-05C

Leukotriene B4 Receptor 1 (LTB4R1, LTB4-R 1, LTB4-R1, LTBR1, Leukotriene B4 Receptor, LTB4R, BLT, BLT1, BLTR, Chemoattractant Receptor-like 1, CMKRL1, G-protein Coupled Receptor 16, GPR16, P2Y Purinoceptor 7, P2RY7, P2Y7)

BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor (Yokomizo et al., 1997). Part of the coding regions of BLTR2 (LS57180) have been duplicated and are part of the 5' UTR noncoding regions of the clusters BLT1 (LS190955) and CIDE-B (LS54843) on chromosome 14. BLT1 has been reported in blood, bone marrow, brain, heart, liver, and skeletal muscle. In addition, BLT1 has been shown to be highly expressed in leukocytes and lymphoid tissues such as spleen, thymus, and lymph node. ESTs have been isolated from B-cell/lung/testis, breast, colon, eye, kidney, skin, spleen, testis, and tonsil libraries.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 7-17ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

L2046-05C

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human Leukotriene B4 Receptor BLT1.

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