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LIN7B, Recombinant, Human, aa1-207, His-Tag (Protein Lin-7 Homolog B, LIN-7B, MALS-2, MALS2, VELI2)

Cat no: 138687

LIN7B, Recombinant, Human, aa1-207, His-Tag (Protein Lin-7 Homolog B, LIN-7B, MALS-2, MALS2, VELI2)

LIN7B, also known as VELI2, belongs to the Velis family. Velis are a family of small synaptic proteins that interact with other proteins at the post-synaptic density (PSD) of neuronal synapses. Velis contain the PDZ motif involved in recruiting cell adhesion molecules, receptors, and channels. Lin7B is ubiquitously expressed with high expression in brain, liver, and testis. It localized at the synaptic junctions in neurons. Lin7B bind to CASK, a neurexin-binding protein highly concentrated in synapses, and Mint1, a binding partner with a vesicle trafficking protein. \n\nSource:\nRecombinant protein corresponding to aa1-207 from human LIN7B at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~25.3kD (230aa) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMAALVEP LGLERDVSRA VELLERLQRS GELPPQKLQA LQRVLQSRFC SAIREVYEQL YDTLDITGSA EIRAHATAKA TVAAFTASEG HAHPRVVELP KTDEGLGFNI MGGKEQNSPI YISRVIPGGV ADRHGGLKRG DQLLSVNGVS VEGEQHEKAV ELLKAAQGSV KLVVRYTPRV LEEMEARFEK MRSARRRQQH QSYSSLESRG\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138687

Size

50ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.2M sodium chloride, 2mM DTT, 50% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Okamoto M., et al. (1997) J Biol Chem. 272:31459-31464-293 Irie M., et al. (1999) 2. Oncogene. 18:2811-2817.

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