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Loperamide hydrochloride

Cat no: L-100

Loperamide hydrochloride

Loperamide hydrochloride is an off the counter medication for treatment of various diarrhea syndromes. By decreasing peristalsis of the intestine, it prolongs the gastrointestinal transit time and increases absorption of fluids and electrolytes from the stool to the gastrointestinal tract. \n\nLoperamide is a synthetic derivative of phenylpiperidine, and is very similar to diphenoxylate, another derivative used to treat diarrhea. It is a strong agonist of micro -opiate receptors found in both the central nervous system and the gastrointestinal tract. Nevertheless, loperamide is considered to be a specific and safe treatment, when administered systemically or orally due to its inability to cross the blood-brain barrier and effect opiatic receptors in the brain.\n\nBesides its effect as an opiate-receptor agonist, loperamide also behaves as a calcium-calmodulin antagonist and was shown to inhibit NMDA receptors, HCN channels, and voltage-gated Ca2+ channels.

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SPECIFICATIONS

Catalog Number

L-100

Size

10g

Purity

>98%

Concentration

1-100 uM

Shipping Temp

Room Temperature

Molecular Weight

513.5 Da

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