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LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)

Cat no: L4500-03A

LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)

Major vault protein (MVP) is the main constituent of vaults which are huge intracellular ribonucleoprotein particles, with their structure resembling cathedral roof vaults. Lung resistance-related protein (LRP) was identified as the major MVP. The approximately 55aa residue MVP domain has a unique, novel fold that consists of a three-stranded antiparallel beta-sheet. It functions as a transport associated protein that can be associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. Expression of MVP:LRP has been documented in various tumors adult T-cell leukemia, osteosarcoma, Wilms' tumor, acute leukemia, prostate carcinoma, ovarian carcinoma, acute myeloid leukemia, and non-small-cell lung cancer where it acts as an excellent predictor and marker of multiple drug resistance (MDR). This gene produces two transcripts by using two alternative exon 2 sequences. It is highly expressed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine and overexpressed in many multidrug-resistant cancer cells.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nBreast\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

L4500-03A

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Rat

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. Abbondanza et al. J Cell Biol 141: 1310, 1998. 2. Kozlov et al. J Mol Biol 356: 444, 2005. 3. Tsutomu et al. Brain Tumor Pathol 19: 59, 2002.

Additional Info

Recognizes rat MVP.

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