LSD1 Polyclonal Antibody (aa 450-500)

Antigen: synthetic peptide from human LSD1 amino acids 450-500 . Host: rabbit . Cross Reactivity: (+) chimpanzee, bovine, canine, equine, human, mouse, orangutan, and porcine LSD1 . Application(s): WB . LSD1 is a lysine-specific histone demethylase that acts as a component of CoREST and other transcriptional co-repressor complexes. It plays an important role in silencing neuronal-specific genes in non-neuronal cells and is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation.

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SPECIFICATIONS

Catalog Number

13486

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Demethylase

Weight

0

Antigen

synthetic peptide from human LSD1 amino acids 450-500

Storage Temp

-20

Shipping Temp

-20

Additional Info

LSD1, the first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domaine. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.