MCAD Polyclonal Antibody

Antigen: human recombinant MCAD . Host: rabbit . Cross Reactivity: (+) human, porcine, ovine, and mouse MCAD; other species not tested . Application(s): WB; other applications not tested . MCAD is a mitochondrial enzyme that catalyzes the first step in the (beta)-oxidation of fatty acids. Its expression is induced during periods of fasting and is regulated by PPAR(alpha), a ligand-activated transcription factor involved in the regulation of lipid homeostasis. MCAD expression can be used as a marker to evaluate the in vivo activity of PPAR(alpha).

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SPECIFICATIONS

Catalog Number

101730

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Fatty Acids|PPAR

Weight

0

Antigen

human recombinant MCAD{7568}

Storage Temp

-20

Shipping Temp

-20

Additional Info

Medium-chain fatty acyl-CoA dehydrogenase (MCAD) is a mitochondrial enzyme that catalyzes the first step in the .beta.oxidation of fatty acids. MCAD expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. The promoter for MCAD contains a peroxisome proliferator response element (PPRE) and is regulated transcriptionally by peroxisome proliferator-activated receptor alpha (PPAR.alpha.), a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Because of this, MCAD expression can be used as a marker to evaluate the in vivo activity of PPAR.alpha. Human MCAD is approximately 87% homologous to porcine and rat MCAD, respectively. MCAD is expressed in liver, heart, kidney, and skeletal muscle.