MCP2, Recombinant, Mouse (Macrophage/Monocyte Chemotactic Protein 2, Chemokine C-C Motif Ligand 8, CCL8, HC14, Monocyte Chemotactic Protein 2, Small Inducible Cytokine A8 Precursor, SCYA8, SCYA10)

MCP-2 (Monocyte Chemoattractant Protein 2), otherwise known as CCL8, is a CC chemokine originally isolated from the human osteosarcoma cell line MG-63, which is expressed at highest levels in peripheral blood cells and the small intestine. MCP-2 acts as a chemoattractant for monocytes, lymphocytes, eosinophils and basophils, and signals through binding to the common MCP receptor, chemokine (C-C motif) receptor 2 (CCR2), and also CCR1 and CCR3. Proteolytic cleavage of MCP-2 into the NH2-terminally truncated form, MCP-2 (6-76), results in the loss of chemotactic activity, forming a functional CC chemokine inhibitor, which may be important during inflammatory responses.\n\nSource:\nE. coli\n\nApplications:\nSuitable for use in Functional Assays. Other applications not tested.\n\nBiological Activity:\nDetermined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml.\n\nEndotoxin: (same/less than)1EU/ug\n\nMolecular Weight: 8.5kD (74 amino acid residues)\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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