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Products MDM2, CK1d, Active, Recombinant, Human, GST-Tag (Ubiquitin-protein Ligase E3 Mdm2, p53-binding Protein Mdm2, Oncoprotein Mdm2, Double Minute 2 Protein, Hdm2)
| Catalogue number: | 029536 |
| Size: | 10ug |
| Form: | Supplied as a liquid in 50mM Tris/HCl pH7.5, 300mM sodium chloride, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. |
| Purity: | ~78% (SDS-PAGE, Coomassie blue staining) |
| References: | 1. Fang S. et al., Mdm2 is a RING Finger-Dependent Ubiquitin Protein Ligase for Itself and p53. J Biol Chem., 275: 8945-8951, 2000. 2. Honda R. et al., Oncoprotein MDM2 is a Ubiquitin Ligase E3 for Tumor Suppressor p53. FEBS Lett. 420:25-27, 1997. 3. Marine J-C. and Lozano G. Mdm2-Mediated Ubiquitylation: p53 and Beyond. Cell Death and Differentiation, 17: 93-102, 2010. 4. Huart A-S. et al., CK1a Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability. J. Biol Chem., 284: 32384-32394, 2009. 5. Sigalas I. et al., Alternatively Spliced Mdm2 Transcripts with Loss of p53 Binding Domain Sequences: Transforming Ability and Frequent Detection in Human Cancer. Nat Med. 2: 912-917, 1996. |
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