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MEK1 (Phospho-Thr386) Polyclonal Antibody

Cat no: 10009517

MEK1 (Phospho-Thr386) Polyclonal Antibody

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 . Host: rabbit . Cross Reactivity: (+) rat MEK1 . Application(s): WB . MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation. MEK1 is phosphorylated by MAPK on Thr292 and Thr386.

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SPECIFICATIONS

Catalog Number

10009517

Applications

WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies|Intracellular Signaling

Weight

0

Antigen

phosphopeptide corresponding to amino acid residues surrounding the Phospho-Thr386 of human MEK1

Storage Temp

-20

Shipping Temp

-20

Additional Info

MAP kinase kinase 1 (MEK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation . This pathway also plays a key role in synaptic plasticity in the brain . Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase . Conversely, there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase are Thr292 and Thr386 .

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