Melanocortin-4 Receptor Polyclonal Antibody

Antigen: mouse MC4R amino acids 21-33 . Host: rabbit . Cross Reactivity: (+) human, mouse, and rat MC4R . Application(s): IHC (formalin-fixed paraffin-embedded sections) and WB . MC4R receptor plays a critical role in appetite regulation and is a prime target for therapeutic intervention in obesity.

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SPECIFICATIONS

Catalog Number

10006355

Applications

IHC, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

mouse melanocortin-4 receptor amino acids 21-33 (YGLHSNASESLGK)

Storage Temp

-20

Shipping Temp

-20

Additional Info

Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'. These actions are mediated (differentially or concurrently) in part by a family of G-protein coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain. Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation. Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. Cayman's MC4R polyclonal antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.