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Products Melanocortin-4 Receptor STEP Reporter Assay Kit (Luminescence)
| Catalogue number: | 600190 |
| Weight: | 0 |
| Form: | 1 ea |
| P type: | Assay Kits|STEP Assays |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | The melanocortin-4 receptor (MC4R) has important roles in weight regulation, sexual function, and inflammation. Mice deficient in MC4R have increased lipid deposition associated with elevated adiposity, while mutations in MC4R in humans are associated with early onset or severe obesity. This assay consists of a 96-well plate coated with both MC4R and Secretory Alkaline Phosphatase (SEAP) reporter constructs. Cells grown on the STEP complex will express MC4R at the cell surface. Binding of agonists to MC4R initiates a signaling cascade resulting in expression of SEAP. SEAP activity is measured following addition of a luminescence-based alkaline phosphatase substrate provided in the kit. |
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