Melanocortin Receptor 5 (MC5-R)

Melanocortins are regulatory peptides formed by post-translational processing of pro-opiomelanocortin. Melanocortin peptides have been suggested to perform a variety of physiological roles ranging from control of behavior, memory, neurotrophic properties, antipyretic and modulation of immune system, etc. Their binding sites have been found distributed in tissues ranging from lachrymal and submandibular glands, pancreas, adipose tissue, bladder, duodenum, spleen, brain, gonadal tissues and malignant melanoma tumors. Five melanocortin receptors have been characterized to date. These include melanocyte-stimulating hormone receptor (MSH or MC1-R), corticoaderenal-specific ACTH receptor (MC2-R), melacortin-3 (MC3-R), melanocortin-4 (MC4-R) and melanocortin-5 receptor (MC5-R). MC3-R and MC4-R are distributed in brain whereas MC5-R has a broad distribution. Mouse, rat , and human Melanocortin receptor 5 (MC5-R) are 325 amino acid transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for MSH (a,b,g) and ACTH. It is found in brain but not in melanocyte. MCR-5 may be involved in immunomodulation properties of melanocortins. mediate t, placenta, and gut tissues.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:10,000-1:1000,000 using 50-100ng control peptide/well.\nWestern Blot: 1-10ug/ml (ECL).\n\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide: M2868-45\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M2868-45A

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

Supplied as a liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.

Additional Info

Recognizes Melanocortin Receptor 5. No significant sequence homology with other receptors. Species sequence homology: Human and rat: 93% (14/15 aa); Porcine, sheep and bovine: 73% (11/15 aa); chicken: 63%.