Deuterated Methotrexate an antineoplastic and antirheumatic. A folic Acid antagonist.
Melting Point:
> 200 degrees C (decomposes)
Solubility:
DMSO; aqueous base
Specific Rotation:
+17.8 degrees (c= 0.4; 0.1N NaOH)
Method for Determining Identity:
Proton NMR spectroscopic analysis and mass spectrometric analysis
TLC Conditions:
C18; Acetonitrile : Water : Ammonium Hydroxide (8ml: 2ml: 10 drops). Visualized with UV an dAMCS (single spot; Rv=0.4).
Storage and Stability:
Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.