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MRGPRX2, CT (MRGPRX2, MRGX2, Mas-related G-protein coupled receptor member X2) (Biotin)

Cat no: 038585-Biotin

MRGPRX2, CT (MRGPRX2, MRGX2, Mas-related G-protein coupled receptor member X2) (Biotin)

MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

038585-Biotin

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Gembardt, F., et al. Mol. Cell. Biochem. 319 (1-2), 115-123 (2008) :\nYang, S., et al. Gene 352, 30-35 (2005) :\nRobas, N., et al. J. Biol. Chem. 278(45):44400-44404(2003)\nTakeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :\nDong, X., et al. Cell 106(5):619-632(2001)

Additional Info

Human

Alternative Names

MRGPRX2, MRGX2, Mas-related G-protein coupled receptor member X2

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