MSK1, phosphorylated (Ser360) (Ribosomal Protein S6 Kinase alpha 5, Nuclear Mitogen-and Stress-activated Protein Kinase 1, 90kD Ribosomal Protein S6 Kinase 5, RSK-like Protein Kinase, RLSK, S6K-alpha-5, RPS6KA5, MSK) (APC)

MSK1 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. This protein plays an essential role in the control of RELA transcriptional activity in response to TNF. Activity of MSK1 requires the presence of both kinase domains.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M4692-46B-APC

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. USA 101(33):12130-12135 (2004). 2.Abecassis, L., et al., J. Biol. Chem. 279(29):30474-30479 (2004). 3.Zhang, Y., et al., Carcinogenesis 25(7):1165-1175 (2004). 4.Zhang, Y., et al., J. Biol. Chem. 279(21):21866-21872 (2004). 5.Li, Y., et al., J. Biol. Chem. 279(2):970-979 (2004).

Additional Info

Recognizes human MSK1 when phosphorylated at Ser360.