Mucins

Mucins are glycoproteins abundant with O-linked oligosaccharides secreted by epithelial mucous membranes. Their protective function is due to their high viscosity. Bovine submaxillary mucin has a molecular weight of 4-40 X 10e5 daltons. The molecule consists of major and minor components with a protein moiety (36.6% of the molecule) and a carbohydrate moiety (56.7% of the molecule). Mucins are heavily glycosylated glycoproteins, which constitute the major components of mucus which cover the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6,7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. Muc-5AC and Muc-6 glycoproteins are the first two mucins found in superficial epithelium and Muc-6 glycoprotein is found in the deep glands.\n\nApplications:\nSuitable as a substrate for neuraminidase assays.\n\nQuality Control:\nSDS-PAGE\n\nStorage and Stability:\nStable for at least 12 months at 4C. Protect from moisture.

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SPECIFICATIONS

Catalog Number

M4700

Size

100mg

Form

Supplied as a lyophilized powder.

Purity

Mucin is prepared by the method of Nisizawa and Pigman [The composition and Properties of the Mucin Clot from Cattle Submaxillary Glands, Arch. Oral Biol., 1:16 (1959)]. Bovine sub-maxillary glands are blended in a phosphate buffer, the material is filtered followed by a pH adjustment, then centrifuged and the ppt is resuspended; a final pH adjustment is made and the material is put in dialysis prior to lyophilization.

Alternative Names

Bovine submaxillary gland