Quick Search
Products Multi-Drug Resistance Assay Kit (Calcein AM)
| Catalogue number: | 600370 |
| Weight: | 0 |
| Form: | 1 ea |
| P type: | Assay Kits |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | P-Glycoprotein (P-gp), the product of the multidrug resistance (MDR) gene MDR1, and multidrug resistance associated proteins (MRP) are members of the superfamiliy of ATP-binding cassette (ABC) transporters. They are localized in the luminal membrane of endothelial cells and function to detoxify or eliminate a spectrum of harmful agents and chemicals by mediating energy-dependent transport from the cell. While their expression in normal cells protects the cells from xenobiotic attack, their expression in other cells, such as cancer cells, can be a significant obstacle to drug efficacy. Cayman's Multidrug Resistance Assay Kit provides a convenient tool for studying MDR protein modulators. The kit employs calcein AM, a substrate for MDR proteins including P-gp and MRP, as a probe for the detection of chemical compounds interacting with MDR proteins. Hoechst Dye is used as a marker of cell nuclei. Cyclosporin A, a competitive inhibitor, and verapamil, a noncompetitive inhibitor, are included as positive controls. |
Get the Best Promotions
