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N-Acetylgalactosaminidase, alpha, Recombinant, Human, 6-His-tag (NAGA, Alpha-galactosidase B, Alpha-N-acetylgalactosaminidase)

N-Acetylgalactosaminidase, alpha, Recombinant, Human, 6-His-tag (NAGA, Alpha-galactosidase B, Alpha-N-acetylgalactosaminidase)

Cat no: A0528-10C

Supplier: United States Biological
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NAGA is a lysosomal that cleaves non-reducinga -N-acetylgalactosaminyl moieties from glycoconjugates. Mature NAGA has 394aa and is trafficked to the lysosome via the mannose-6-phosphate receptor-mediated pathway. The enzyme is a retaining exoglycosidase, where both the substrate and product of the enzymatic reaction have the same anomeric configuration. Deficiency in NAGA results in increased urinary excretion and tissue accumulation of glycopeptides and oligosaccharides containing terminal a-N-acetylgalactosaminyl moieties, manifesting as Schindler
Catalogue number: A0528-10C
Size: 20ug
Form: Supplied as a liquid in Tris, sodium chloride, Brij, glycerol. BSA free.
Purity: ~95% (SDS-PAGE)
References: 1. Wang, A.M. et al. (1990) J. Biol. Chem. 265:21859. 2.Sweeley, C.C. et al. (1983) Arch. Biochem. Biophys.223:158. 3. Garman, S.C. et al. (2002) Structure. 10:425. 4. Eng, C.M. et al. (2001) N. Engl. J. Med. 345:9. 5. Wang, A.M. et al. (1990) J. Clin. Invest. 86:1752. 6.Liu, Q.P. et al. (2007) Nature Biotechnol. 25:454. 7. Calcutt, M. J. et al. (2002) FEMS Microbiol. Lett. 214:77. 8. Zhu, A. et al. (1996) Arch. Biochem. Biophys. 327:324.

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