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Products Nampt Monoclonal Antibody (Clone OMNI 379)
| Catalogue number: | 10813 |
| Hosts: | Mouse |
| Applications: | ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 100 microg |
| Antigen: | recombinant human Nampt |
| P type: | Antibodies |
| Isotype: | IgG2ak |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Nampt is a 52 kDa adipokine secreted by adipose tissue that is involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates the insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. |
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