Nampt Monoclonal Antibody (Clone OMNI 379)

Antigen: recombinant human Nampt . Host: mouse, clone OMNI 379 . Cross Reactivity: (+) human, mouse, and rat Nampt . Application(s): ELISA, FC, ICC, IHC, IP, and WB . Nampt is an adipokine involved in the biosynthesis of NAD+ and is highly expressed in visceral fat. It promotes vascular smooth muscle cell maturation, inhibits neutrophil apoptosis, and activates the insulin receptor with insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. Serum levels of Nampt correlate with obesity.

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SPECIFICATIONS

Catalog Number

10813

Applications

ELISA, FC, ICC, IHC, IP, WB

Hosts

Mouse

Form

100 microg

P Type

Antibodies

Weight

0

Antigen

recombinant human Nampt

Isotype

IgG2ak

Storage Temp

-20

Shipping Temp

-20

Additional Info

Nampt is a 52 kDa adipokine secreted by adipose tissue that is involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates the insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.