Home  >  Products  >  NDRG1 (Protein NDRG1, Differentiation-related Gene 1 Protein, DRG-1, N-myc Downstream-regulated Gene 1 Protein, Nickel-specific Induction Protein Cap43, Reducing Agents and Tunicamycin-responsive Protein, RTP, Rit42, CAP43, DRG1)
NDRG1 (Protein NDRG1, Differentiation-related Gene 1 Protein, DRG-1, N-myc Downstream-regulated Gene 1 Protein, Nickel-specific Induction Protein Cap43, Reducing Agents and Tunicamycin-responsive Protein, RTP, Rit42, CAP43, DRG1)

NDRG1 (Protein NDRG1, Differentiation-related Gene 1 Protein, DRG-1, N-myc Downstream-regulated Gene 1 Protein, Nickel-specific Induction Protein Cap43, Reducing Agents and Tunicamycin-responsive Protein, RTP, Rit42, CAP43, DRG1)

Cat no: N2915-52E

Supplier: United States Biological
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NDRG1 is a member of the emerging NDRG family involved in stress responses, hormone responses, cell growth, and differentiation. The NDRG1 gene is mapped to human chromosome 8q24.2 and encodes a cytosolic protein containing three unique tandem repeats of 10 hydrophilic aa near the C-terminus. Expression of NDRG1 is markedly upregulated in various cells under such conditions as cell differentiation, hypoxia and exposure to heavy metals. However, its expression is repressed by the Myc family transcription factors and after cellular transformation. Mutations in the NDRG1 gene are linked to the hereditary motor and sensory neuropathy. The protein is ubiquitously expressed in human and rat heart, brain, kidney, placenta, lung, liver, skeletal muscle, and pancreas. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of human brain, kidney and testis on ~48kD bands. Immunohistochemistry (Paraffin): 2-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N2915-52E
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhou D, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998 May 15;58(10):2182-9.
Additional info: Recognizes human NDRG1. Species sequence homology: Canine, mouse and rat.

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