Neuropeptide Y receptor type 1 (NPY1-R)

NPY1R, Neuropeptide Y receptor Y1, is a protein that in humans is encoded by the NPY1R gene. NPY receptor is a member of the G protein-coupled receptor superfamily. The NPY Y1 receptor gene has 3 exons. By high resolution fluorescence in situ hybridization, the NPY1R gene is localized to chromosome 4q31.3-q32. NPY is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle.\n\nUniProt Number:\nP25929\n\nGene ID:\nNPY1R\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144956

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Cavadas, C., Cefai, D., Rosmaninho-Salgado, J., Vieria-Coelho, M. A., Moura, E., Busso, N., Pedrazzini, T., Grand, D., Rotman, S., Waeber, B., Aubert, J.-F., Grousmann, E.Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion.Proc. Nat. Acad. Sci. 103: 10497-10502, 2006.2.\n2. Herzog, H., Baumgartner, M., Vivero, C., Selbie, L. A., Auer, B., Shine, J.Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.J. Biol. Chem. 268: 6703-6707, 1993.\n3. Herzog, H., Hort, Y. J., Ball, H. J., Hayes, G., Shine, J., Selbie, L. A.Cloned human neuropeptide Y receptor couples to two different second messenger systems.Proc. Nat. Acad. Sci. 89: 5794-5798, 1992.

Additional Info

Recognizes human, mouse and rat NPY1R. No crossreactivity with other proteins.