Home  >  Products  >  Neutrophil Defensin 1, 3 (Defensin, alpha 1, HNP-1, HP-1, HP1, DEFA1, DEF1, DEFA2, MRS, DEFA1B/Defensin, alpha 3, HNP-3, HP-3, HP3, DEFA3, DEF3)
Neutrophil Defensin 1, 3 (Defensin, alpha 1, HNP-1, HP-1, HP1, DEFA1, DEF1, DEFA2, MRS, DEFA1B/Defensin, alpha 3, HNP-3, HP-3, HP3, DEFA3, DEF3)

Neutrophil Defensin 1, 3 (Defensin, alpha 1, HNP-1, HP-1, HP1, DEFA1, DEF1, DEFA2, MRS, DEFA1B/Defensin, alpha 3, HNP-3, HP-3, HP3, DEFA3, DEF3)

Cat no: N5377-03P

Supplier: United States Biological
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Defensin alpha 1, otherwise known as HNP-1, is a secreted cationic antimicrobial peptide and member of the alpha-defensin family, which plays an important role in the innate immune response against microbial infections. Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Applications: Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 1-3ug/ml Immunohistochemistry (Paraffin): 4-6ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N5377-03P
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Chang TL, Vargas J Jr, DelPortillo A, Klotman ME. Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J Clin Invest. 2005 Mar;115(3):765-73.
Additional info: Recognizes human DEFA1,3.

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