NF-kB (p50) Monoclonal Antibody (Clone 2J10D7)

Antigen: a portion of amino acids 150-200 of human NF-kB (p50) . Host: mouse, clone 2J10D7 . Isotype: IgG1k . Cross-Reactivity: (+) human NF-kB (p50) . Application(s): IHC and WB . NF-kB1 (p50) is a 50 kDa functional sub-unit of NF-kB that forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NF-kB (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding.

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SPECIFICATIONS

Catalog Number

13755

Applications

IHC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies|NF-.kappa.B|Intracellular Signaling

Weight

0

Antigen

a portion of amino acids 150-200 of human NF-kB (p50)

Isotype

IgG1k

Storage Temp

-20

Shipping Temp

-20

Additional Info

NF-kB is a transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation. NF-kB1 (p50), a 50 kDa functional sub-unit of NF-kB, is a member of the Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing a nuclear localization signal, DNA-binding and dimerization domains. NF-kB (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NF-kB (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. A pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.