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Nicotinamide N-methyltransferase, 1-264aa, Recombinant, Human (NNMT)

Cat no: N2561-70A

Nicotinamide N-methyltransferase, 1-264aa, Recombinant, Human (NNMT)

NNMT(Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.\n\nSource:\nRecombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E.coli.\n\nMolecular Weight: 31.7kD (284aa)\n\nSequence of amino acids:\nMGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE\nGLFSLVARKL SRPL\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at 20 or 70 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N2561-70A

Size

100ug

Form

Supplied as liquid in 20mM Tris-HCl, pH8.0, 20% glycerol.

Purity

(same/more than)95% (SDS-PAGE)

References

1. Parsons RB., et al. (2002). J Neuropathol Exp Neurol. 61(2):111-24. 2. Smith ML., et al. (1998). Biochim Biophys Acta. 1442(2-3):238-44.

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