Antigen: fusion protein from the C-terminus of the NR2A subunit of rat NMDA receptor . Host: rabbit . Cross Reactivity: (+) human, mouse, and rat NMDA receptor . Application(s): IHC, IP, and WB . The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. Channels with physiological activity are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.