nNOS Polyclonal Antibody

Antigen: human nNOS amino acids 1422-1433 . Host: rabbit . Cross Reactivity: (+) rat and human nNOS; (-) iNOS and eNOS . Application(s): ICC, IHC, IP, and WB . NOS catalyzes the oxidation of arginine to nitric oxide and citrulline. nNOS is a soluble enzyme found in brain, the peripheral nervous system and skeletal muscle. In neurons, protein-protein interactions with PSD95 and PSD93 via the PZD domain at the N-terminus of nNOS localizes the enzyme with NMDA receptors.

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SPECIFICATIONS

Catalog Number

160870

Applications

ICC, IHC, IP, WB

Hosts

Rabbit

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

human nNOS amino acids 1422-1433 (ESKKDTDEVFSS){1280,4153}

Storage Temp

-20

Shipping Temp

-20

Additional Info

Nitric oxide synthase (NOS) catalyzes the oxidation of arginine to nitric oxide (NO) and citrulline. Three distinct isoforms of NOS have been described having nomenclature based on the tissue source from which they were originally cloned. These three isoforms are neuronal/brain NOS (nNOS/bNOS/NOS-I), inducible NOS (iNOS/NOS-II), and endothelial NOS (eNOS/NOS-III). nNOS is a soluble enzyme found in brain, the peripheral nervous system and skeletal muscle. An alternately spliced form of nNOS (nNOS . ) containing a 34 amino acid insert has been identified in skeletal muscle. In neurons, protein-protein interactions with PSD95 and PSD93 via the PZD domain at the N-terminus of nNOS localizes the enzyme with NMDA receptors. Although nNOS was originally thought to be constitutively expressed, abundant evidence suggests expression is regulated by a variety of conditions.