

Supplier:
Cayman Chemical CompanyCat no: 10004942
Nod2 Monoclonal Antibody (Clone 2D9)
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SPECIFICATIONS
Catalog Number
10004942
Applications
IHC, WB
Hosts
Mouse
Form
1 ea
P Type
Antibodies|Intracellular Signaling
Weight
0
Antigen
human recombinant Nod2 amino acids 28-301
Storage Temp
4
Shipping Temp
4
Additional Info
Nod2 is a member of the apoptosis regulating protein family that has caspase recruitment-domains (CARDs) and also includes Apaf-1 and Nod1. Nod2 contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). Nod2 is expressed in monocytes whereas Nod1 (CARD4) is expressed in multiple tissues. Both Nod1 and Nod2 act as intracellular receptors for bacterial lipopolysaccharides, activate NF-kB, and contribute to inflammatory bowel disease. A frameshift mutation in the NOD2 gene is associated with susceptibility to Crohn's disease, possibly by causing truncation of the tenth LRR. Cayman Chemical's NOD2 Monoclonal Antibody can be used for western blot and immunohistochemical analysis of Nod2 on samples of human origin. The antibody will also recognize three Nod2 polymorphisms: L1007finsC, G908R, and R702W.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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